Usually distribution tools and analytics tools are different software products.

For analytics there are MicrostockAnalytics (desktop software), StockPerformer (web-based service).
For uploading and/or automatic submission there are picWorkflow, LightBurner (web-based services) and StockSubmitter (desktop software).

As of security these tools are there for the long time so I guess they can be considered safe.
For the absolute safety I'd recommend desktop software though as in that case you can be sure your logins and passwords are stored only on your computer and will never be sent anywhere except the agencies.
Also, AFAIK StockPerformer does not keep your logins/passwords and uses your existing agencies authentication in your browser.