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CD123 - So sorry to hear about all the setbacks and I wish you the best. I feel I can really relate to your situation as I too have serious heart disease, a pile of other chronic diseases, and I struggle with depression (which usually comes out as irritation and anger, like nearly assaulting a guy twice my size because he was not climbing up the escalator ). While not the sole cause of my depression, the impact of my chronic diseases on my life is significant and ongoing. I’m fortunate to work with a great team of doctors and a fantastic therapist so I’m doing OK. Hopefully you are able to get treatment for you depression, as there are treatments you can do that likely will make a big difference. While taking a short break from MSG might help, based on my experience, the one thing I would say is that depression thrives on withdrawal. The more I pulled away from things that did or might frustrate me, the more depressed I got in the long term. If MSG is too frustrating, I urge you to replace it with something else (not necessarily stock related) that lets you find “a place” again. I did that when I stopped reading/participating in the Istock forums and joined MSG and I’m much happier for it.PS I picked my screen name as I was sad about what happened to Istock, not because I get depressed.