Nothing as good as Noiseware IMHO
http://imagenomic.com/Products/Noiseware

Yes, it cost more, but it is not so more expensive for the more quality that you can get.
I think that when you have a Nikon D850 you should expect to get the best result from the softwares you use for the post production, so you have no reason to not spend a little more to get the best softwares

As I know it is not possible to use directly from Lightroom.
Not a big problem by the way, it is just a step more to open the file from Lightroom in Photoshop, and then apply the Noiseware filter.

Quality: I would not say that Define is a bad software, it is not. But personally I never liked it, I find that it generates “plastic” images (and blurry contours/edges) compared to Noiseware, and I find the use of the control points very tricky and imprecise.
But I admit that I have not a great experience with this software.

Noiseware can work in selective way on different colors (and intensity of color), on different level of luminosity, on different levels of frequency (all combined, e.g dark saturated blues with average noise frequency).
It has also an excellent detail enhancement module.
Noiseware is the only software that I have tried (and I have tried a lot) that gives me a very good denoising together with a very good sharpening.

You can also use bracketing, so the software generates various level of intensity of the denoising/sharpening that you can then compare and choose in few clicks.

At last I think that everybody should use the software he feels better to use

Yes, it cost more, but it is not so more expensive for the more quality that you can get.
I think that when you have a Nikon D850 you should expect to get the best result from the softwares you use for the post production, so you have no reason to not spend a little more to get the best softwares

As I know it is not possible to use directly from Lightroom.
Not a big problem by the way, it is just a step more to open the file from Lightroom in Photoshop, and then apply the Noiseware filter.

Quality: I would not say that Define is a bad software, it is not. But personally I never liked it, I find that it generates “plastic” images (and blurry contours/edges) compared to Noiseware, and I find the use of the control points very tricky and imprecise.
But I admit that I have not a great experience with this software.

Noiseware can work in selective way on different colors (and intensity of color), on different level of luminosity, on different levels of frequency (all combined, e.g dark saturated blues with average noise frequency).
It has also an excellent detail enhancement module.
Noiseware is the only software that I have tried (and I have tried a lot) that gives me a very good denoising together with a very good sharpening.

You can also use bracketing, so the software generates various level of intensity of the denoising/sharpening that you can then compare and choose in few clicks.

At last I think that everybody should use the software he feels better to use

Thank you Chichikov,
very interesting review.
I will certainly look into it. So, it also does sharpening?

Just curious as I don't own such a high end camera...how often and at what ISO do you feel the need to use NR software...I wouldn't have expected the need to be that frequent?

Hi Pauws,
to be honest I was expecting the D850 to have excellent tolerance of nose even with high ISO.
I am frankly surprised to notice that I do get the first hint of noise at about ISO 640 (as I show in this video). At ISO 1800 things get really bad (at least in my experience).
It does not bother me too much because the D850 has an incredible magic ability to recover shadows, I mean even images underexposed by 4 to 5 stops are perfectly recovered!
Also the base ISO is 64 and I get extremely good results with the extended low ISO (which I believe is 32), so I have more than 4 stops of clean ISO to play with